Aaron Hoffman, PhD

Dr. Aaron Hoffman's research focuses on the molecular epidemiology of cancer, with a particular interest in the influence of genetic and epigenetic mechanisms of circadian disruption on cancer susceptibility. He is also interested in more broad analyses of the inter-individual variability in gene expression, and the extent to which epigenetic mechanisms such as post-transcriptional gene regulation by small non-coding RNA species and other non-traditional regulatory instruments (e.g. alternative polyadenylation), influence cancer-relevant processes and contribute to the complex risk structure which is observable at the population level. In each case, the goal of his research is to generate insights with translational implications which may be useful for the treatment and prevention of cancer.