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Trop Med Seminar: Dr. James McLachlan presents "Adjuvant selection regulates gut migration and phenotypic diversity of antigen-specific CD4+ T cells following parenteral immunization."


Downtown Campus

Tidewater Room 504 JBJ

Diarrheal diseases are the second leading cause of death in children under five. Developing effective parenterally (non-mucosally) delivered vaccines targeted to combat mucosal infections is essential. We show that intradermal immunization with non-toxic double-mutant heat-labile toxin (dmLT) drives endogenous, antigen-specific CD4+ T cells to expand and migrate into the intestines. We also find dmLT produces a balanced Th1, Th2, and Th17 response. Immunization with dmLT engages CD103+ dendritic cells which license antigen-specific T cell migration to the mucosa following parenteral immunization.

For more information on the DTM Seminar Series please contact Dr. Patricia Scaraffia or Dr. Juan Pizarro.