Monday, November 27, 2017 -
Diarrheal diseases are the second leading cause of death in children under five. Developing effective parenterally (non-mucosally) delivered vaccines targeted to combat mucosal infections is essential. We show that intradermal immunization with non-toxic double-mutant heat-labile toxin (dmLT) drives endogenous, antigen-specific CD4+ T cells to expand and migrate into the intestines. We also find dmLT produces a balanced Th1, Th2, and Th17 response. Immunization with dmLT engages CD103+ dendritic cells which license antigen-specific T cell migration to the mucosa following parenteral immunization.