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Department of Tropical Medicine Seminar Series: Gene Therapy Strategies for AIDS

Downtown Campus
Tidewater Building (1440 Canal Street, New Orleans, LA 70112)
Room 2302

Featuring Dr. Stephen E. Braun Assistant Professor, TU

We are genetically modifying CMV-specific T cells with anti-HIV CAR vectors to redirect the immune response towards HIV-infected cells. These bicistronic vectors express the CD4 extracellular domains to bind HIV Env, intracellular T cell signaling domains to activate cytotoxicity, and a membrane associated fusion inhibitor to protect the CAR Tc from infection. To increase the targeting of latent reservoirs, we are using the novel reactivation potential of adipose-derived mesenchymal stem cells.

For more information on the DTM Seminar Series please contact Dr. Patricia Scaraffia, pscaraff@tulane.edu