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GBDS Courses

View current course offerings at the Office of the Registrar.

BIOS 6030 INTRODUCTORY BIOSTATISTICS (3) This is a beginning course in applied biostatistics. The objective of the course is to introduce the student to biostatistical methods and to understand the underlying principles, as well as practical guidelines of “how to do it” and “how to interpret it” as the role they can play in decision making for public health majors. The course covers both graphical and numerical methods of describing data sets, an introduction to probability and probability distributions, estimation, hypothesis testing, power and sample size estimations. Faculty: S. Srivastav, A. Shankar, J. Lefante, Y. Liu. Offered: Every Semester. Prerequisite(s): None.

BIOS 6040 INTERMEDIATE BIOSTATISTICS (3) This is an intermediate course in applied biostatistics. The course covers Analysis of Variance and Multiple Regression and Correlation Analysis, and Logistic Regression. The focus will be on numerical computation and interpretation of results of statistical application using statistical packages. Faculty:  A. Shankar, H. Qin, W. Tang, J. Lefante. Offered: Fall and Spring. Prerequisite(s): BIOS 6030 and one of BIOS 6230, 6240, 6270, 6280.

BIOS 6220 DATABASE MANAGEMENT (3) An introduction to the principles and application of data management, techniques in data collection, data cleaning, data reporting, database design, and implementing databases for managing large data systems. After taking the course, students will be able to create databases with applications to public health intervention and surveillance, use SQL to administrate, management, and retrieve data for statistical analysis. Faculty: J. Zhao, J. Shaffer. Offered: Spring. Prerequisite(s): Basic knowledge of MS Office.

BIOS 6230 COMPUTER PACKAGES SAS (1) Introduces SAS (Statistical Analysis System) to students who are new to the program. Students will develop essential SAS programming skills for analysis of medical and health-related data. Faculty: J. Shaffer, Y. Liu. Offered: Every Semester. Prerequisite(s): BIOS 6030.

BIOS 6240 COMPUTER PACKAGE FOR SPSS (1) Introduction to SPSS (Statistical Package for the Social Science) for Windows for data management and analysis. Provides a foundation for the use of the SPSS software through example programs that analyze health-related data sets. Students will develop technical skills necessary for analysis of health-related data sets. Faculty: T. Niu. Offered: Every Semester. Prerequisite(s): BIOS 6030.

BIOS 6270 Introduction to R (1) Introduces the R computer package for students who are new to statistical programming in R. Topics include creating, importing, and updating data files, managing, restructuring and exporting data, constructing graphs by applying plotting functions, and performing basic statistical analysis using R. Students will develop critical analytic capabilities in performing various statistical tasks, e.g., descriptive and exploratory data analysis, conducting analysis of variance, ANOVA, and fitting linear models. Faculty: T. Niu. Offered: Every Semester. Prerequisite(s): BIOS 6030 concurrent.

BIOS 6280 INTRODUCTION TO STATA (1) Introduces STATA to students who are new to the program.  Uses STATA to mage data by creating, updating and restructuring data files. Students will be able to use STATA to accomplish a variety of statistical tasks such as computing summary statistics, creating visual displays of data, performing a variety of statistical tests including Student’s t test and analysis of variance (ANOVA), and constructing a linear regression model. Faculty: T. Niu. Offered: Every Semester. Prerequisite(s): BIOS 6030 concurrent.

BIOS 6300 INTRODUCTION TO ArcGIS (1) This course covers the elementary concepts and applications for mapping using the ArcGIS software.  The course focuses on a wide variety of public health applications and is applicable to virtually all academic and professional settings where mapping is used.  Each lecture begins with a PowerPoint presentation to introduce fundamental mapping concepts and is followed with in-class exercises to reinforce hands-on application.  Two in-class, paper-based exams are given to monitor and assess students’ understanding of the course concepts. Faculty: T. Niu, J. Shaffer. Offered: Every Semester. Prerequisite(s): BIOS 6030 concurrent.

BIOS 6310 INTRODUCTION TO METHODS IN DATA SCIENCE (3) This blended course introduces practical methods for using large datasets to gain insights that are transforming biomedical research. Students will learn technologies used by today's data science practitioners, such as the Python programming language, databases and SQL query language. Students will have hands-on experience applying these software tools to real-world examples with datasets in genetics and electronic health records. Through interactive discussions of current research articles, students learn how data science is being used to make important discoveries in biology and medicine. The learning environment incorporates online course materials and face-to-face lectures.  Faculty: L. Gragert, A. McCoy. Offered: Fall (Hybrid). Prerequisite(s): Students are expected to have basic computer knowledge.

BIOS 6350 ENVIRONMENTAL BIOSTATISTICS (3) The objective of this course is the application of statistical methods to the collection and analysis of environmental data. The focus of the course will be on field sampling designs for air, soil and water samples, statistical techniques relating to environmental data and developing predictive models for environmental data. Faculty: A. Shankar. Offered: Fall. Prerequisite(s): BIOS 6030; BIOS 6230 or BIOS 6240.

BIOS 6800 PUBLIC HEALTH GIS (3) The course is an introduction to desktop mapping and spatial analysis. The first part of the course covers geographic information systems (GIS) concepts and mapping using the ArcGIS software. The second part of the course covers introductory spatial analytical techniques, including spatial autocorrelation quantification, cluster analysis, and spatial modeling. The student will develop a public health GIS project that requires the synthesis of mapping and spatial analysis. Faculty: J. Shaffer. Offered: Spring. Prerequisite(s): BIOS 6220.

BIOS 6850 PRINCIPLES OF BIOINFORMATICS (3) This course introduces basic bioinformatics algorithms used in analysis of biological sequence data. These algorithms represent the theoretical foundations for the latest bioinformatics analytical methods, including next generation sequencing data analyses. Faculty: Y. Liu. Offered: Fall. Prerequisite(s): None.

BIOS 7060 REGRESSION ANALYSIS (3) This is an advanced course on selected statistical techniques for analyzing data on multiple variables, both continuous and categorical. This course ultimately provides the student with insight into the application of regression techniques to the medical and health sciences. It focuses on statistical methodology wiht emphasis on selection of appropriate applications and interpretation of results. Faculty: J. Li. Offered: Fall and Spring. Prerequisite(s): BIOS 6030 & 6040; and one of BIOS 6230, 6240, 6270, 6280.

BIOS 7080 DESIGN OF EXPERIMENTS (3) This course deals with fundamental topics in design of experiments including principle theory of experimental designs (randomization, replication, and balance). It focuses the main elements of statistical thinking in the context of experimental design such as completely randomized design, randomized complete block design, experiments with two factors, factorial design, nested designs, repeated measurement design, and split-plot designs. Faculty: S. Srivastav. Offered: Spring. Prerequisite(s): BIOS 6030 & 6040; and one of BIOS 6230, 6240, 6270, 6280.

BIOS 7150 CATEGORICAL DATA ANALYSIS (3) Fundamental concepts and methods for analysis of categorical outcomes.  Topics include analysis of 2-way tables, unconditional and conditional logistic regression, power and sample size computation, and modeling of dependent categorical outcomes via mixed models and GEE methods.  Course covers the mathematical basis of the statistical procedures but the emphasis is on application of the methods using statistical software and interpretation of results. Faculty: L. Myers. Offered: Fall. Prerequisite(s): BIOS 6030 & 6040; and one of BIOS 6230, 6240, 6270, 6280.

BIOS 7220 NONPARAMETRIC STATISTICS (3) Nonparametric inferential statistical methods are introduced. Topics include single, paired, independent, and multiple sample hypothesis testing and confidence interval methods; n parametric regression and correlation methods; categorical data and measures of concordance. Faculty: L. Myers, J. Lefante, S. Srivastav. Offered: Spring. Prerequisite(s): BIOS 6030, BIOS 6040, and at least one of BIOS 6230, BIOS 6240, or BIOS 6280.

BIOS 7250 PRINCIPLES OF SAMPLING (3) This course introduces core principles of survey sampling, with emphasis on sampling plans, methods of estimating unknown parameters of population and subdomain, and techniques for calculating precisions of the estimators. Topics include: basic concepts in survey sampling, simple random sampling; stratified random sampling; systematic sampling; one-, two- and multi-stage cluster sampling; probability appropriate to size sampling. Faculty: H. Qin, J. Lefante. Offered: Spring. Prerequisite(s): BIOS 6030; and one of BIOS 6230, 6240, 6270, 6280.

BIOS 7300 SURVIVAL DATA ANALYSIS (3) Topics include analysis of survivorship data including estimation and comparison of survival curves, regression methods in the analysis of prognostic and etiologic factors, concepts of competing risks, and the analysis of clinical trial data. Software used for problem solving. Emphasis placed on the application of methods to the analysis of public health data with examples of clinical trials, cancer survivorship, and other data sets for which there is partial follow-up of subjects. Faculty: W. Tang, J. Lefante. Offered: Fall. Prerequisite(s): BIOS 6030 & 6040, and one of BIOS 6230, 6240, 6270, 6280.

BIOS 7380 BAYESIAN INFERENCE (3) This course examines theoretical foundations and applications of Bayesian paradigm, including Bayes' theorem, prior distribution, likelihood function, deriving posterior distributions, and point and interval estimations. Assessment of convergence, the evaluation of models, and the presentation of the results are also illustrated. Real world examples drawn from medical research are used to show practicality of Bayesian napproach, particularly how to update beliefs and make inferences from observed data. Faculty: T. Niu. Offered: Spring '17 (Initial Course Offering) Prerequisite(s): BIOS 6030 & 6040; and one of BIOS 6230, 6240, 6270, 6280.

BIOS 7400 CLINICAL TRIALS (3) Covers design, implementation, analysis and reporting of clinical trials. Topics encompass trial design, hypothesis formulation and testing, methods of randomization, ethics, sequential trials, sample size determination, blinding, subject recruitment, data collection and management, quality control, monitoring outcomes and adverse events, interim analysis, statistical methods in analyzing trial data, and addressing scientific issues in reporting and interpreting trial results. Faculty: T. Niu. Offered: Every other Fall. Prerequisite(s): BIOS 6030 & 6040; and one of BIOS 6230, 6240, 6270, 6280. Concur: BIOS 6030, BIOS 6230, BIOS 6240.

BIOS 7450 Population and Quantitative Genetics (3) This course provides a comprehensive introduction to empirical and theoretical population and quantative genetics. Basic models of population and quantitative genetics are presented as well as the primary forces and processes involved in shaping genetic variation in natural populations. Students learn to use the methods of measuring genetic variation in nature, and recent experimental tests of important ideas in population and quantitative genetics. Faculty: H. Shen. Offered: Fall. Prerequisite(s): BIOS 6030 & 6040, and one of BIOS 6230, 6240, 6270, 6280.

BIOS 7550 EPIGENETICS AND EPIGENOMICS (3) Provides a comprehensive, state-of-the-art introduction to basic and advanced knowledge of epigenetics and epigenomics. Reviews the principles and recent progresses in epigenetic regulation of gene transcription, epigenome-environment interactions, and roles of epigenetic and epigenomic mechanisms in disease etiology. Introduces current and emerging techniques and methodologies for assessing epigenetic features. Presents and discusses recent cutting-edge epigenetic and epigenomic studies. Faculty: H. Shen. Offered: Fall. Prerequisite(s): TRMD 6780 or background in molecular biology, molecular genetics or genetic epidemiology.

BIOS 7650 STATISTICAL METHODS IN BIOINFORMATICS(3) This course provides detailed overviews over the evaluation and application of statistical learning theories and techniques for inference and prediction in data science, particular for biological and public health data. Topics include linear and nonlinear models, resampling techniques, tree-based methods, unsupervised learning such as clustering, support vector machine, graphical models, etc. Working on real and/or simulated data through assignments, students will apply the knowledge learned and practice their skills in solving various biological and public health problems, such as sequence alignment, gene prediction, subtype identification and classification, and disease risk and prognosis prediction. Discussion on model assessment and selection are also included. Faculty: Jian Li. Offered: Fall. Prerequisite(s): BIOS 6030, one of BIOS 6230/6240/6280, BIOS 6040; or instructor approval

BIOS 7750 BIOINFORMATICS APPROACHES TO TRANSCRIPTOMICS (3) This course is a comprehensive and in-depth overview and discussion on a wide spectrum of bioinformatics and statistical topics related to transcriptomics. The major focus is on various stages and aspects of bioinformatics and statistical analyses of transcriptomics data. Faculty: Y. Liu. Offered: Spring. Prerequisite(s): BIOS 6030.

BIOS 7990 MASTERS INDEPENDENT STUDY(1-3)  Faculty: Faculty. Offered: Every Semester. Prerequisite(s): None.

BIOS 8000 DOCTORAL STUDENT JOURNAL CLUB (0) This course is intended to improve students' ability in interpreting, evaluating, critiquing, presenting, and communicating the elements, concepts, findings, and implications from current Biostatistics and Bioinformatics research literatures in a seminar setting.  All enrolled students will be expected to give at least one oral presentation and participate in the student-led discussions.  Feedback to each presenter will be given orally, in writing and/or through e-mails by faculty and peer students.  At the end of the course, students will gain experience in assessing the value of research findings from selected publications to biostatistics and bioinformatics research. Faculty: H. Deng. Offered: Every Semester. Prerequisite(s): Enrollment in Doctoral Program or Instructor Approval.

BIOS 8100 STATISTICS IN HUMAN GENETICS (3) This course is concerned with the statistical analysis of human genetics data. The objective of this course is to introduce the students to the concepts and principles of human statistical genetics and to the rational for related analytical approaches. The topics include analytical methods for genetic markers such as single nucleotide polymorphisms, next generation sequence data, and statistical analyses for disease susceptibility gene mapping such as linkage analysis and association study, and other topics such as methods in population structure detection. Faculty: J. Li. Offered: Fall. Prerequisite(s): At least one of: BIOS 7450, BIOS 7060, BIOS 7080 or equivalent or instructor’s approval.

BIOS 8200 CAUSAL INFERENCE FOR BIOMEDICAL INFORMATICS (3) This course covers basic concepts and selected state-of-the-art statistical methods and theory of causal inference for biomedical informatics. It will empower students to draw causal conclusions and make predictions by mining data from observational and experimental studies. Topics include: targeted machine learning, structural equation modeling, Mendelian randomization, and heteroskedastic genomic prediction. Faculty: H. Qin. Offered: Every other Spring. Prerequisite(s): BIOS 6030 & 6040; BIOS 7060; MATH 6080; and at least one of BIOS 6230, 6240, 6280.

BIOS 8350 CLUSTERED AND LONGITUDINAL DATA ANALYSIS (3) This is an advanced course in analysis of clustered and longitudinal data, with or without missing values. Students will compute power and sample size for clustered and longitudinal data using generalized linear mixed effect models and estimating equations. Class discussion, lecture, and assignments emphasize application of methods to the analysis of public health data with examples of clinical trials and epidemiological observational studies. Use of standard statisitical software and methods required. Faculty: W. Tang. Offered: Every other Spring. Prerequisite(s): BIOS 6030; BIOS 6040 or 7060; and at least one of BIOS 6230, 6240, 6270, 6280.

BIOS 8500 MONTE CARLO AND BOOTSTRAPPING METHODS (3) This hands-on course introduces the methods used for Monte Carlo simulations and nonparametric bootstrapping. Students learn how to design, program, and interpret a simulation study, uses of bootstrapping for estimation and inference, jackknifing, and other resampling methods. Monte Carlo Markov Chain methods and Bayesian inference in Monte Carlo methods will be introduced. This is an advanced, computer-intensive course, so knowledge of programming language (SAS or R preferred) as well as ability to work independently are required. Faculty: L. Myers. Offered: Every other Spring. Prerequisite(s): At least 2 of 5 selected BIOS 7000 level courses:  7060, 7080, 7150, 7220, 7300.

BIOS 8800 APPLIED DATA ANALYSIS (3) This is an advanced methods course for hands-on data analysis and management. Students use real datasets to formulate testable hypotheses, interrogate and clean data, implement appropriate strategies for missing data, design and perform appropriate analyses, and keep written documentation of their analyses. Students also learn how to interpret and effectively report the results of statistical analyses, both orally and in writing. Use of a statistical software package is required, preferably SAS. Faculty: L. Myers. Offered: Every other Fall. Prerequisite(s): At least 2 of 5 selected BIOS 7000 level courses:  7060, 7080, 7150, 7220, 7300.

BIOS 8820 MULTIVARIATE METHODS (3) This is a doctoral level course that covers techniques used to conduct analysis with more than one outcome variable. The focus will be on association methods and predictive models between multiple independent and multiple dependent variables. Additionally the students will learn techniques for variable reduction, path models, and factor analysis. Students will conduct numerical computation and interpretation of results of statistical application using statistical packages. Faculty: A. Shankar. Offered: Every other Fall. Prerequisite(s): Doctoral status required. Students should have completed at least two 7000 level biostatistics courses and have working knowledge of programmable statistical software, (SAS, R, STATA).

BIOS 8990 DOCTORAL INDEPENDENT STUDY(1-3) Faculty: Faculty. Offered: Every Semester. Prerequisite(s): None.

BIOS 9970 Dissertation (0) May register for this after defending prospectus. Faculty: Faculty. Offered: Every Semester. Prerequisite(s): None.

BIOS 9980 Master's Thesis (0) Faculty: Faculty. Offered: Every Semester. Prerequisite(s): None.

BIOS 9990 Dissertation Research (2) Students may register for this after passing the comprehensive exam. Faculty: Faculty. Offered: Every Semester. Prerequisite(s): None.